Is immunohistochemistry mandatory in staging bone marrow trephine biopsy of patients with diffuse large B-cell lymphoma (DLBCL)

Diffuse large B-cell lymphoma (DLBCL) can be found involving bone marrow in approximately 11-27% of cases 1. Patterns of involvement are variable; these include diffuse pattern (lymphomatous cells diffusely infiltrating the marrow), interstitial pattern (i.e. small amount of lymphomatous cells scattered among hematopoietic cells), nodular pattern (lymphomatous cells forming aggregates in intertrabecular or paratrabecular area of the marrow).. ...

Author : Jitsupa Treetipsatit, M.D.

Primary sinonasal mucosal melanoma with CD138 expressed plasmacytoid cells: a case report and review of literature

Primary sinonasal mucosal melanoma is a rare neoplasm. Like in other sites of malignant melanoma, the histopathology is variable and when lacking of melanin pigment, particularly in small biopsy specimen mimicks many neoplasms. Immunohistochemical staining plays an important role. Many immunomarkers, including S-100, HMB-45 and Melan-A should be...

Author : Narida Chirakalwasan, M.D.*
Category : Case Reports

Increased eosinophil levels in HIV-infected patients with high CD4/CD8 ratio Study from 564 patients in Ramathibodi Hospital.

Blood from 564 patients infected with human immunodeficiency virus (HIV) were studied for laboratory analysis. The hematological changes including white blood cell count (WBC), percentage and absolute number of lymphocyte and eosinophil were determined by using the Technicon H*3 RTX hematological analyzer. Analysis of blood cell parameters...

Category : Original Articles

Advantage of frozen section in management of thyroid nodule with preoperative fine needle aspiration in Siriraj Hospital, Bangkok, Thailand

We aimed to evaluate the role of frozen section (FS) and preoperative fine-needle aspiration cytology (FNA) in thyroid nodular lesions. ...

Category : Original Articles

Diagnostic Pitfalls of Prostatic Adenocarcinoma in Biopsy Specimens

Prostatic adenocarcioma is a very common male cancer worldwide. Biopsy remains the most reliable means in making definite diagnosis. In the prostate-specific antigen (PSA) screening era, the rate of prostate biopsies rapidly increases, resulting in early detection of very small tumors. In the same time, general pathologists are forced to face...

Category : Special Articles