[P-01] A study of the MRI and pathologic features of 66 cases of primary central nervous system lymphoma

Truong Phan Xuan Nguyen1 and Thi Ngoc Ha Hua2

  1. Department of Pathology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
  2. Department of Pathology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

 

Background and Objectives: Primary central nervous system lymphoma (PCNSL) was an uncommon variant of extranodal non-Hodgkin lymphoma. Contrast-enhanced MRI imaging was the method of choice for detecting PCNSL. The purpose was to describe the MRI and pathologic features of PCNSL and to determine whether there was a correlation between it.

Materials and Methods: A series of 66 cases of PCNSL were diagnosed at the Department of Pathology, Cho Ray Hospital, from January 2016 to November 2018.

Results: Sixty-six cases were immunocompetent which had mean age 55 ± 12 years old. The monofocal lesion was predominant (77.27%). Basal ganglia and periventricular brain parenchyma were the most common site of involvement (23.86%). The mean size was 3.80 ± 1.78 cm. The lesions were hyperintense on T1-weighted images (66.67%), and 89.39% hypointense on T2-weighted images. These patients had enhancing lesions (98.48%) and perifocal oedema (36.36%). Diffuse large B-cell lymphoma (DLBCL) was predominant in all the cases (72.24%). Vascular destruction pattern was presented in high proportion (χ2, p < 0.05). The correlations between the perivascular infiltrative pattern and the vascular destruction were statistically significant (Fisher, p < 0.05). Corticoid usage before biopsy was related to necrosis (Fisher, p < 0.05). The solid enhancing lesions were correlated with the density of tumour (Fisher, p < 0.05).

Conclusion: PCNSL is a rare tumour in central nervous system. The vast majority of PCNSL have a B-cell origin, particularly DLBCL. In the proper clinical and radiologic setting, suggesting the diagnosis of PCNSL can help institute proper treatment in a timely fashion and avoid unnecessary attempts at surgical resection.