The X-chromosomal short tandem repeats analysis in Thai population

Human variations in the X chromosome are useful tools in studying human genetic diversity and individual identification. Five X chromosomal short tandem repeats (X-STRs) multiplex system (DXS8378, DXS101, HPRTB, DXS8377 and DXS10011) were amplified in one single polymerase chain reaction. ...

Protective effect of angiopoietin 2 on cardiomyocytes against simulated ischemic injury

Angiopoietin 1 (Angpt1) and Angiopoietin 2 (Angpt2) are vascular growth factors that play important roles in vascular angiogenesis and adult vasculature maintenance. Previous studies reported that Angpt1 reduced the size of myocardial infarction in in vivo myocardial infarction experiment in rats, while Angpt2  protein levels increased in myocardial infarction areas. ...

Cytotoxic effect of lutein extracts from marigold flower in Lens epithelial cell line

Lutein is a carotenoid found in the lens of the human eyes. Its functions are to protect the eyes by filtering a hazard blue light and to prevent vision loss due to cataract formation. Lutein could not be synthesised in the body and must be taken from the diet, however, lutein is isolated from a marigold flower....

A Comparison Study of Molecular Classification of Primary Invasive Breast Carcinoma and Corresponding Metastatic Carcinoma in Axillary Lymph Nodes by Immunohistochemistry

Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumours as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance....

Pathological Assessment of Activity and Chronicity Indices in Lupus Nephritis Patients

Lupus nephritis (LN) is one of a major complication of systemic lupus erythematosus (SLE). Ten percent of patients with LN will develop end-stage renal disease (ESRD). Renal biopsy is the gold standard for diagnosis of LN and evaluate activity and chronicity of disease to predict renal function outcome....

Physicians’ knowledge, attitude and practices towards autopsy in a Nigerian tertiary hospital

The post-mortem examination is a hospital service necessary to diagnose the cause and circumstances surrounding patients' death. This study assessed the knowledge, attitude and practices of physicians towards autopsy. Descriptive cross-sectional study of physicians that completed a semi-structured questionnaire assessing their knowledge...

The detection of HLA-B27 allele types by quantitative real-time polymerase chain reaction with melting curve analysis

Human leucocyte antigen B27 (HLA-B27) is a major histocompatibility complex class 1 molecule that is strongly associated with ankylosing spondylitis. The polymerase chain reaction with sequence specific primers (PCR-SSP) is currently used for the discrimination of HLA-B27 allele types resulting from single base substitutions....

Assessment of the usefulness of the knowledge of Pathology for clinical medical students - A multi-center study

Pathology courses are taught to undergraduate medical students to provide them with basic foundation for clinical sciences. However, there is hardly any form of assessment of how relevant and helpful these pathology courses are to the students in the clinical years and even beyond. ...

Predictive Biomarker Testing in Colorectal Cancer: KRAS and BRAF Mutation Frequency and Testing Algorithm in Developing Countries

Predictive biomarker testing is mandatory before initiating targeted therapy in metastatic colorectal cancer (mCRC). Mutation frequencies and their association with clinicopathological features vary widely across populations. In low socio-economic countries, appropriate selection of cases is important for biomarker testing....

Acute and subchronic oral toxicity of xanthones extracted from the pericarp of Garcinia mangostana Linn.in rat

The purpose of this research was to study the acute and subchronic toxicity of crude mangosteen pericarp hydro extract, and determine the appropriate and safe amount of extract that may be consumed, through testing with Sprague Dawley rats of both sexes. The soft layer of the inner pericarp mangosteen fruits was immersed in water and boiled at 70 OC, and...