Hepatitis B Virus infection is not a risk factor in liver fluke-associated cholangiocarcinoma – a comparative study of P53 mutation between groups with Opisthorchis viverrini and HBV infection

Pairojkul C¹,Sithithaworn P², Yongvanit P³, Waraasawapati S¹, Chamagramol Y¹

¹Department of Pathology

²Department of Parasitology and

³Department of Biochemistry

Faculty of Medicine, Khon Kaen Unisersity, Khon Kaen, Thailand

Objective: To investigation the role of HBV infection as a risk factor in liver fluke-associated cholangiocar-cinoma In Northeast (NE) Thailand, people are exposed to numerous risk factors for cholangiocarcinoma, such as: infestation with the liver fluke, Opisthorchis vivenini, hepatitis B virus (HBV) and hepatitis c virus (HCV) infection, and nitrosamine contamination from traditional fermented dishes. The meta-analysis of Asian cholangiocarcinoma revealed that the relative risks of infection with liver fluke, HBV and HCV were 4.8,2.6, and 1.8, respectively. Among Thai people the prevalence ofHBsAg, and anti- HCV were 8-10% and 0.89-5%, respectively.