[P-15] Paediatric gastric adenocarcinoma: two case reports and literature review
Thu D.A. Phan1, Nhu T.Q. Nguyen2 and Quynh P. Bui1
- Department of Pathology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
- Department of Haemato-Oncology, Children's Hospital 2, Ho Chi Minh City, Vietnam
Background: Paediatric gastric adenocarcinoma (GAC) is an extremely rare with limited relevant data. Until now, the clinical presentation and outcome have not yet been thoroughly understood.
Case Presentation: Two boys (10 and 14 years old) were admitted to hospital with severe malnutrition. Abdominal CT demonstrated the tumour protruding into stomach, irregular border, peritoneal metastasis. Gastric biopsies showed pleomorphic cells along with variable size and increased N/C ratio. These cells arranged into sheet growth pattern, cluster of cells or uncomplete tubules with neutrophils infiltrating. The malignant cells showed strong expression of CK and negativity for CD99, NSE, myogenin, CD3, CD20, ALK and CD30. Both cases were consistent with poorly differentiated gastric adenocarcinomas, diffuse type with lymphovascular invasion.
Discussion and Conclusion: Paediatric GAC presented with more advanced stage and poorly differentiation. However, the clinical presentation is similar to adult GAC. Because of data limitation, the diagnosis and treatment of paediatric GAC remains a significant challenge. Additional molecular investigations including E-cadherin or HER2 testing of the tumour samples may offer more choices of treatment for these patients.