[P-38] Analysis of ETS-like protein 1 expression on prostate adenocarcinoma in West Sumatera, Indonesia
Anandia Putriyuni1,2, Yevri Zulfiqar3 and Tofrizal4
- Rasidin Hospital, Padang, Indonesia
- Department of Anatomical Pathology, Faculty of Medicine, Baiturrahmah University, Padang, Indonesia
- Division of Urology, Department of Surgery, Faculty of Medicine, Andalas University / M. Djamil Hospital, Padang, Indonesia
- Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, Indonesia
Background and Objectives: Prostate cancer is the second most common and the fifth leading cause of death by cancer in men worldwide. The most diagnosed type of prostate cancer is adenocarcinoma. ETS-like protein 1 (Elk-1) is a member of the ETS-domain transcription factor family. Elk-1 signaling pathways support growth and progression of tumour cells. However, the mechanism of Elk-1 in prostate adenocarcinoma remains unclear. Analysis of Elk-1 expression on prostate adenocarcinoma has never been carried out in the population of West Sumatera. Therefore, this study aimed to analyse Elk-1 expression correlated with Gleason score of prostate adenocarcinoma in West Sumatera, Indonesia.
Materials and Methods: As many as 56 samples (slides and paraffin blocks) of prostate adenocarcinoma were collected from Anatomical Pathology Laboratories in West Sumatera. Gleason score (GS) was determined according to the International Society of Urological Pathology (ISUP) 2014/WHO 2016. Immunohistochemical staining of Elk-1 protein was also applied.
Results: Prostate adenocarcinoma in this study had a high GS (scores of 8 – 10). Approximately 76.79% of cases had GS of 9 (44.64%) and 8 (28.57%). The tumour cells showed positive Elk-1 immunoexpression in 34 (60.71%) cases. Approximately 88.24% of prostate adenocarcinoma with high GS revealed higher levels of positive Elk-1 expression by comparison with Elk-1-negative cases. There was statistically significant correlation between Elk-1 expression and GS (p = 0.012).
Conclusion: Elk-1 signaling pathway is likely to be activated in prostate adenocarcinoma as it promotes growth and progression of the tumor cells. Elk-1 is potential as prognostic biomarker for prostate adenocarcinoma.