[OA-20] High-risk histopathologic features of retinoblastoma: correlation with prognosis

Panuwat Kongtrakun¹, Rangsima Aroonroch¹, Duangnate Rojanaporn², Nattawat Asawaworarit² and Suradej Hongeng³

1. Department of Pathology, Facolty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
2. Department of Ophthalmology, Facolty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
3. Department of Paediatrics, Facolty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Retinoblastoma is the most common malignant intraocolar tumour in children. It has been shown that adjuvant therapy following enucleation in patient with high-risk histopathologic features significantly decrease the mortality. We described the association of histopathologic features with prognostic factors. The aim of this study was to determine the correlation between histopathologic features and prognosis of retinoblastoma. Based on retrospective case series, we evaluated the clinical data, histopathologic features and prognostic factors of 57 retinoblastoma patients who were treated by enucleation at Ramathibodi Hospital, between 2009 and 2019. Twenty-eight of 57 patient (49%) had high-risk histopathologic features. Extraocolar extension (p < 0.001) and marginal invasion (p < 0.001) were associated with all prognostic factors. Post-laminar optic nerve invasion (p = 0.001) was associated with survival, death and metastasis. Massive choroidal invasion (p = 0.005) was associated with survival and death. Scleral invasion (p < 0.001) was associated with survival. Another histopathologic feature; tumour size including basal diameter (p = 0.002) and thickness (p < 0.001) were associated with prognostic factors. In conclusion, high-risk histopathologic features and tumour size are associated with prognosis of retinoblastoma.

Keywords: high-risk histopathologic features; prognosis; retinoblastoma