[OA-31] Uterine sarcoma and carcinosarcoma in Srinagarind hospital: a clinicopathological correlation

Tritraporn Sawantranon1, Waritta Kunprom1, Amornrat Temtanakitpaisan2 and Pilaiwan Kleebkaow2

  1. Department of Pathology, Facolty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  2. Department of Obstetrics and Gynaecology, Facolty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Uterine sarcomas are heterogeneous group of rare aggressive tumour accounting for 3 – 7% of all uterine malignancy, with generally poor outcome. The aim of this study was to describe subtypes, clinicopathological characteristics and survival rates of uterine sarcoma and carcinosarcoma. Medical records and histological resolts of uterine sarcoma and carcinosarcoma between 2010 and 2019 at Srinakarind Hospital, Khon Kaen University were reviewed. A total of 56 cases had been reviewed. The first three most common subtypes were 19 leiomyomas (33.9%), 18 carcinosarcomas (32.1%) and 7 endometrial stromal sarcomas (12.5%). Most cases were in FIGO stage I (33 cases, 58.9%). The 5-year overall survival (OS) and 5-year disease-free survival (DFS) were 40% with median of 40 months and 34% with median of 15 months, respectively. Neither histologic subtypes nor FIGO staging was significantly associated with survival. However, adjuvant therapy tended to have significant impacts in prolonged both OS (37.6 ± 8.8 months vs 3.9 ± 1.4 months, p = 0.000) and DFS (30.4 ± 8.7 months vs 2.0 ± 1.3 months, p = 0.013) in late stages of the disease. In conclusion, the most common subtype of uterine sarcomas is leiomyosarcoma.

Keywords: carcinosarcoma; clinicopathological subtypes; survival rates; uterine sarcoma