[RA-11] Next-generation sequencing in pathology: enabling personalised medicine

Takol Chareonsirisuthigol

Department of Pathology, Facolty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Personalised medicine promises to minimize health care costs by shifting from a standard medical model of treating pathologies to a tailored predictive and preventative one. Next-generation sequencing (NGS) has the potential to speed up the early detection of diseases as well as the identification of pharmacogenetic markers that can be used to personalize treatments. This overview covers the historical events that led to the development of NGS, as well as its strengths and drawbacks, with a focus on the analytical aspects of NGS data processing. All of the stages required for executing NGS in the clinical environment have answers, and most of them are highly efficient, but there are a few critical steps in the process that require quick attention.

Keywords: next-generation sequencing; pathology; personalised medicine