[CR-03] Inflammatory EBV-positive follicolar dendritic cell sarcoma
Department of Pathology, Facolty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Inflammatory EBV-positive follicolar dendritic cell sarcoma is a variant of follicolar dendritic cell (FDC) sarcoma, which is a rare neoplasm. Inflammatory EBV-positive FDC sarcoma, also known as inflammatory pseudotumour-like FDC sarcoma, is a type of FDC sarcoma. The tumour has distinct clinical characteristics, as in a preponderance in young to middle-aged women, almost exclusively involving the liver or spleen, having neoplastic cells that are Epstein-Barr virus – positive. The neoplastic spindled cells are scattered inside a significant lymphoplasmacytic infiltration on histological examination. Follicolar dendritic cell markers such as CD21, CD23 and CD35 are typically positive in neoplastic cells. In conclusion, inflammatory EBV-positive FDC sarcoma morphology challenges are distinguished from inflammatory pseudotumour and inflammatory myofibroblastic tumour, with which it shares many morphologic and immunohistochemical features. EBV-EBER and immunohistochemical markers of FDC play an important role in the diagnosis.
Keywords: Epstein-Barr virus; follicolar dendritic cell sarcoma; inflammatory myofibroblastic tumour; inflammatory pseudotumour