Nunjaiya R. M.D., PongsakMahanupab M.D.
Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Objective: To assess arelationship between serum prostate specifi c antigen (PSA) levels and pathologic
parameters in radical prostatectomy (RP) specimens for prostate cancer in Chiang Mai University Hospital,
Chiang Mai, Thailand.
Materials and Methods: The study included all patientswho underwent RP for prostatic adenocarcinoma
during January 2007 to December 2015. Patient demographics, preoperative serum PSA and pathological
parameters, including pathological diagnosis, Gleason score, tumor volume, lymph-vascular invasion (LVI),
perineural invasion (PNI), capsular invasion, seminal vesicle involvement and adjacent organ and nodal
metastasis, were obtained. Pearson correlations coeffi cient (r) was calculated to assess relationship between
serum PSA levels and tumor volume.Relationship between serum PSA and the other pathological parameters
were assessed by Spearman’s correlations analysis.
Results: Sixty-fi vemen (mean age of 65.6 years, range 54-79 years) underwent RP with mean preoperative
PSA of 19.09 ng/ml (range, 0.3-101.6 ng/ml).There was a signifi cant correlation between preoperative serum
PSA levels and tumor volume (r = 0.45, p = 0.0002). Serum PSA levels were signifi cantly correlated with
seminal vesicle involvement (r = 0.4142, p = 0.0006), nodal metastasis (r = 0.4079, p = 0.0007) and LVI
(r = 0.279, p = 0.0244). The majority Gleason and Gleason combining scores are weakly correlatedto
pathological parameters, except majority Gleason score with capsular invasion.
Conclusion: The preoperative serum PSA levels appear to be an important prognostic indication of tumor
volume, seminal vesicle involvement and nodal metastasis.