Sanya Sukpanichnant
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Telephone : +662-419-6504 (office); +6686-895-0550 (mobile)
Fax : +662-411-4260 E-mail :
* Partly presented in a lecture on “Histologic Transformation in Lymphoma” given to the 9thLymphoma
Education Conference “New Frontiers in Lymphoma” on September 12, 2015 in Bangkok, Thailand,
organized by Thai Lymphoma Study Group (TLSG) under the Thai Society of Hematology.
** Partly presented in text as a review article on “Histologic Transformation in Lymphoma” published in
Thai language in the Journal of Hematology and Transfusion Medicine on July-September 2015 issue,
volume 25, number 3, pages 235-9.
Received : 21st september 2015; Accepted : 30th October 2015


Morphologic approach is still very crucial to detect transformation in malignant lymphoma. With the knowledge of each malignant lymphoma type, especially the clinical course, a number of lymphoma can have histologic progression as evidence of transformation as follow: large cell transformation, blastic transformation, and histiocytic
transformation. Pathologists need to be aware of the transformation in lymphoma as the disease develops more aggressive clinical course in most cases and at times it is challenging to distinguish this condition from composite lymphoma and secondary neoplasm. This review together with illustrative examples will emphasize on practical points for morphologic approach upon making diagnosis of transformation in lymphoma.