Predictive Biomarker Testing in Colorectal Cancer: KRAS and BRAF Mutation Frequency and Testing Algorithm in Developing Countries

Predictive biomarker testing is mandatory before initiating targeted therapy in metastatic colorectal cancer (mCRC). Mutation frequencies and their association with clinicopathological features vary widely across populations. In low socio-economic countries, appropriate selection of cases is important for biomarker testing....

Hematidrosis or Hematofolliculohidrosis: Report of the Second Case with Complete Histopathologic and Immunologic Studies and a Review of the Literature

Hematidrosis, or bloody sweat, is a rare phenomenon with enigmatic pathogenesis. We present our second case of hematidrosis in a 13-year-old Thai girl that had bloody sweat frequently observed on her back, hands, legs and feet. Skin biopsy revealed areas of hemorrhage in the panniculus and blood-filled spaces in the dermis....

Low-Grade Central Osteosarcoma of Ilium, A Case Report

Low-grade central osteosarcoma accounts for 1-2% of all osteosarcomas, and is usually found in long bones of extremities. To our best knowledge, low-grade central osteosarcoma of pelvic bone is unusually rare....

Thrombotic microangiopathy with Atypical Posterior Reversible Encephalopathy Syndrome (PRES) after kidney transplantation. A case report.

Neurological manifestation of thrombotic microangiopathy (TMA) after renal transplantation is rare and difficult to be distinguished from other conditions. A 51-year-old female with ESRD of unknown etiology received deceased donor kidney transplantation from a 57-year-old donor....

Gap Analysis Study before Implementation of Thailand’s National Guidelines for Point of Care Testing at Chiang Rai Province

The Bureau of Laboratory Quality Standards has published Thailand’s National Guidelines for Point-of-Care Testing (POCT) since August 2015. Still yet, the implementation of the guidelines is a great challenge....

Keyword : poct, point of care

Rate of Dyserythropoiesis-like Nuclear Changes in Erythroid Precursors in Bone Marrow

Dyserythropoiesis-like post-mortem changes in erythroid precursors at autopsy can look similar to certain kinds of pathologic processes. Objective: This study is to evaluate nuclear changes in erythroid precursors in marrow aspirate smears and histologic sections at different intervals...

Update in Thymoma for Surgical Pathologists

Thymoma is the most common mediastinal tumor in adulthood. By definition, it is a thymic epithelial neoplasm that displays at least some characteristics of normal thymus. Microscopically it comprises an admixture of thymic epithelial cells and immature T lymphocytes in various proportions and demonstrates marked intratumoral heterogeneity...

Acute and subchronic oral toxicity of xanthones extracted from the pericarp of Garcinia mangostana Linn.in rat

The purpose of this research was to study the acute and subchronic toxicity of crude mangosteen pericarp hydro extract, and determine the appropriate and safe amount of extract that may be consumed, through testing with Sprague Dawley rats of both sexes. The soft layer of the inner pericarp mangosteen fruits was immersed in water and boiled at 70 OC, and...

Contribution of MYC FISH in Pathological Diagnosis of Burkitt Lymphoma

Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma typically with MYC rearrangement. Distinction between BL and diffuse large B cell lymphoma (DLBCL) is not infrequently encountered in routine practice. In this communication, we report our experience with the MYC break-apart probe FISH in the diagnosis of BL in 19 cases of...

Myocardial infarction without coronary artery atherosclerosis: pathological aspect

Myocardial infarction (MI) is a clinico-pathological condition resulted from an irreversible ischemic injury to cardiac myocytes. Myocardial infarction with normal coronary artery on angiogram (MINCA) is a widelyaccepted clinical term used to describe a group of patients presenting with the MI symptoms and signs but having a normal angiogram....